This week saw a large number of Microsoft patches
Additionally Adobe released updates for Flash and Adobe Air. Acrobat and Reader updates expected for this week will occur next week.
Apple patched the iPhone and released an update for QuickTime. iTunes users were not given the QuickTime update as of this post.
To stay up on all these updates, home users should install something like te Secunia Personal Software Inspector. Sysadmins should wave the dead chicken and hope for the best make plans to deploy these updates if the software is present in the work environment.